CAS NO.56-85-9 L-glutamine

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CAS NO.56-85-9 L-glutamine
Details
CAS: 56-85-9
MF: C5H10N2O3
MW: 146.14
EINECS: 200-292-1
Appearance: White crystals or crystalline powder
Storage : Store below +30°C.
Category
Other Intermediates
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Description

Description

 

L-glutamine ( CAS: 56-85-9, Synonyms: (2,5-Diamino-5-oxpentanoicacid;LEVOGLUTAMIDE;L(+)-GLUTAMINE;L-GLUTAMINE;L(+)-GLUTAMIC ACID-5-AMIDE;L-GLUTAMIC ACID 5-AMIDE;L-GLUTAMIC ACID AMIDE;L-GLN)is an encoded amino acid in protein synthesis and one of the twenty non-essential amino acids. In the human body, it can be synthesized from glutamic acid, valine, and isoleucine, or derived from glucose. L-Glutamine is involved in the formation of purine and pyrimidine nucleotides, amino sugars, glutathione, L-glutamic acid, and other amino acids, and participates in protein synthesis and the production of glucose. Unlike most other amino acids, L-glutamine is unstable in solution. The degradation rate is a function of time, temperature, and pH. L-Glutamine (non-sterile) powder should be prepared as a filter-sterilized stock solution of 200 mM (or a similar concentration) in distilled water. The optimal concentration depends on the cell type and the culture medium used for cell cultivation, but it typically ranges from 2 to 6 mM.

 

◆Chemical Properties

 

Melting Point

185 °C (dec.) (lit.)

Specific Rotation

32.25 ° (c=10, 2 N HCl)

Boiling Point

265.74 °C (rough estimate)

Bulk Density

640 kg/m³

Density

1.47 g/cm³ (20°C)

FEMA

3684

Refractive Index

6.8 ° (C=4, H₂O)

Flash Point

185 °C

Storage Conditions

Store below +30°C.

Solubility

25 mg/mL in water

Acid Dissociation Constant (pKa)

2.17 (at 25°C)

Form

Solution may darken during storage

Color

White

   
   

◆Applications

 

Sr. No.

Description

Application

1

Metabolic Fuel & Precursor

Primary fuel for enterocytes; precursor for glutathione synthesis.

2

Intestinal Barrier Support

Maintains intestinal barrier integrity, prevents mucosal atrophy.

3

Immune Support

Essential fuel for lymphocytes and macrophages; modulates immune response.

4

Anabolic Support

Reduces muscle protein breakdown; supports protein synthesis under stress.

5

Sickle Cell Disease Therapy

FDA-approved to reduce acute complications (Endari®).

 

◆Product Specifications

L-Glutamine (CAS NO.56-85-9) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

  • Use appropriate personal protective equipment (PPE)
  • Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
  • Handle in controlled, well-ventilated environments
  • Keep away from heat, sparks, open flames and hot surfaces
  • Protect from moisture and avoid contact with water
  • Follow chemical handling, storage and containment protocols
  • Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

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