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Name
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2 - hydroxypropyl - α - cyclodextrin
|
|---|---|
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Synonyms
|
HYDROXYPROPYL - ALPHA - CYCLODEXTRIN, MS = 0.6;
alpha - Cyclodextrin, 2 - hydroxypropyl ethers; (2 - Hydroxypropyl) - alpha - cyclodextrin average Mw ~1,180; (2 - Hydroxypropyl) - α - cyclodextrin; HPACD; (2 - Hydroxyethyl) - α - cyclodextrin; 2 - hydroxypropyl - α - cyclodextrin |
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CAS
|
128446 - 33 - 3
|
|
EINECS
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451 - 510 - 9
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|
Related Categories
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Other Biochemical Reagents; Chelation/Complexation Compounds; Cyclodextrins; Synthetic Reagents
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|
Structural Formula
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Structural formula of hydroxypropyl - α - cyclodextrin
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|
Melting Point:
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245 °C (dec.) (lit.)
|
|
Density:
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1.39 at 24.6 °C
|
|
Form:
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Solid powder
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|
Color:
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White to off - white
|
|
Optical Rotation:
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[α]²⁰/D +125°, c = 1 in H₂O
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|
LogP:
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- 10.6~ - 9.89
|
|
Solubility:
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Soluble in water, methanol, DMF. Insoluble in acetone, chloroform.
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| Usage |
1. Pharmaceutical Field: Enhancing Pharmaceutical Formulation PerformanceImproves the water solubility of poorly soluble drugs and increases bioavailability, making drugs more easily absorbed by the human body. Enhances drug stability, reduces degradation reactions such as oxidation and hydrolysis, and lowers drug irritation to the gastrointestinal tract. 2. Food and Cosmetics Fields: Optimizing Product QualityIn food, it can mask the unpleasant odors and bitterness of functional ingredients, stabilize active substances such as flavors and pigments, and extend shelf life. In cosmetics, it can solubilize fat-soluble functional ingredients (e.g., vitamins, plant extracts), reduce irritation, and improve product mildness. |
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