Cefixime Basic information
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Product Name: |
Cefixime |
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Synonyms: |
YTTERBIUM(III) IONOPHORE I;)(carboxymethoxy)imino)acetylamino)-3-ethenyl-8-oxo-,(6r-(6-alpha,7-beta(z)));cl284635;fk027;fr17027;8-[[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid;(6R,7R)-7-[2-(2-AMINO-4-THIAZOLYL)GLOXYLAMIDO]-8-OXO-3-VINYL-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 72-(Z)-[O-(CARBOXYMETHYL)OXIME]TRIHYDRATE;CEFIXME TRIHYDRATE |
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CAS: |
79350-37-1 |
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MF: |
C16H15N5O7S2 |
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MW: |
453.45 |
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EINECS: |
616-684-4 |
Cefixime Chemical Properties
| Melting point | 218-225°C |
| density | 1.85±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Slightly soluble in water, soluble in methanol, sparingly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. |
| pka | pKa 2.10 (Uncertain) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Water Solubility | 55.11 mg/L |
| BCS Class | 4 |
| Stability: | Hygroscopic |
Cefixime Usage And Synthesis
| Chemical properties | White or light yellow crystalline powder, odorless or slight smell. Soluble in ethanol or dimethyl sulfoxide, slightly soluble in acetone, almost insoluble in ethanol, hexane, ethyl acetate or water. Acute toxicity mindanao. Mouse, rat (mg/kg): All> 10,000 orally; 5000,7000 intravenous injection. (Z)-Cefixime Disodium：C16H13N5O7S2Na2. Melting point＞250℃. (E)-Cefixime trihydrate: C16H15N5O7S2 3H2O?. A pale yellow solid, melting point is 218~225 ℃ (decomposition). |
| Uses | The third-generation oral cephalosporin class of broad-spectrum antibiotics, has strong antibacterial effect on Gram-positive bacteria such as Streptococcus, and Gram-negative bacteria such as Neisseria gonorrhoeae, Haemophilus influenzae, , as well as E. coli , Klebsiella pneumoniae, Proteus mirabilis, which are resistance to cefaclor, cephalexin, cefadroxil resistant, and is stable for β-lactamase produced by various bacteria. Long-acting, efficient and can be administered once a day. Clinically used for respiratory tract infections,urinary tract infections and biliary tract infections caused by susceptible strains. |
| Chemical Properties | Cefixime is an oral third generation cephalosporin antibiotic. It was sold under the trade name Suprax in the United States until 2003. The oral suspension form of "Suprax" was re-launched. Cefixime is prescribed for bacterial infections of the chest, ears, urinary tract, and throat (tonsilitis and pharyngitis), and for uncomplicated gonorrhea, upper and lower respiratory tract infections, acute otitis media, and gonococcal urethritis. |
Mechanism
The antibacterial mechanism of cefixime is similar to that of other third-generation cephalosporins. By combining with one or more penicillin binding proteins (PBPs), it inhibits the cell wall synthesis of bacterial dividing cells. PBPs are located on the plasma membrane of bacterial cells and may be catalytic enzymes at the end of bacterial cell wall synthesis. The effect of this product is to cause bacteria to form defective cell walls that are unstable to osmotic pressure, thereby playing an antibacterial effect. Different strains have their own unique PBPs. The different affinity of cefixime to different PBPs is the main factor affecting its antibacterial spectrum activity.
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