![CAS：400827-64-7 7β - Amino - 3 - [4 - (pyridin - 2 - Thiazole Sulfone Radical)] - 3 - Cephem - 4 - Carboxylic Acid·2HCl](/uploads/24095/cas-400827-64-7051db.png)
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Name
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7β - Amino - 3 - [4 - (pyridin - 2 - thiazole sulfone radical)] - 3 - cephem - 4 - carboxylic acid·2HCl
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Synonyms
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7β - Amino - 3 - [4 - (pyridin - 2 - thiazole sulfone radical)] - 3 - cephem - 4 - carboxylic acid·2HCl·
[4 - [(6R,7R) - 7 - amino - 2 - carboxy - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - en - 3 - yl]thio] - methyl pyridinium chloride hydrate; 7β - Amino - 3 - [4 - (pyridin - 2 - thiazole sulfone radical)] - 3 - cephem - 4 - carboxylic acid·2HCl·
[4 - [(6R,7R) - 7 - amino - 2 - carboxy - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - en - 3 - yl]thio] - methyl chloride hydrate; Ceftaroline main chain; Ceftaroline mother core; (dihydrochloride);
7 - [7 - Amino - 2 - carboxy - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - en - 3 - yl]thiomethyl pyridinium chloride monohydrate; 7 - [7 - Amino - 2 - carboxy - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - en - 3 - yl]thiomethyl pyridinium chloride;
7 - [7 - Amino - 2 - carboxy - 8 - oxo - 5 - thia - 1 - azabicyclo[4.2.0]oct - 2 - en - 3 - yl]thiomethyl pyridinium chloride hydrochloride
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CAS
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400827 - 64 - 7
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MF
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C₁₆H₁₅ClN₄O₅S₃
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MW
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479.42424
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EINECS
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447 - 990 - 4
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Related Categories
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Cephalosporin intermediate; Intermediate raw materials; Pharmaceutical fine chemical raw materials
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Storage Conditions
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Inert atmosphere, Room Temperature
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| Usage | The ceftaroline nucleus is the primary raw material for the synthesis of ceftaroline fosamil. The antibacterial mechanism of ceftaroline fosamil involves binding to penicillin‑binding proteins, thereby exerting bactericidal activity. It exhibits strong antibacterial activity against Gram‑positive anaerobes, Staphylococcus aureus, Streptococcus pneumoniae, Gram‑negative anaerobes, MRSA, and other drug‑resistant Gram‑positive bacteria. It also shows inhibitory effects against Escherichia coli, Haemophilus influenzae, penicillin‑resistant pneumococci, Klebsiella oxytoca, and Klebsiella pneumoniae. |
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