CAS 7154-73-6 1-(2-Aminoethyl)pyrrolidine

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CAS 7154-73-6 1-(2-Aminoethyl)pyrrolidine
Details
CAS 7154-73-6
MF C₆H₁₄N₂
MW 114.19
Category
Cephalosporin Intermediates
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Description
Name
1-(2-Aminoethyl)pyrrolidine
Synonyms
1-pyrrolidinoethanamine;
2-(1-Pyrrolidinyl)ethanamine;
2-(1-Pyrrolidinyl)ethylamine;
2-Pyrrolidinoethylamine;
1-(2-Aminoethyl)pyrrolidine, 99%;
1-(2-Aminoethyl)pyrrolidine 98%; 
1-(2-AMINOETHYL)PYRROLIDINE
CAS No.
7154-73-6
MF
C₆H₁₄N₂
MW
114.19
EINECS No.
230-509-5
Melting Point
219 °C (decomp)
Boiling Point
66 - 70 °C / 23 mmHg (lit.)
Density
0.901 g/mL at 25 °C (lit.)
Refractive Index
n20/D 1.468(lit.)
Flash Point
118 °F
Storage Conditions
Keep in dark place. Inert atmosphere. Room temperature.
pKa Values
pK1: 6.56(+2); pK2: 9.74(+1)(30°C)
Form
Liquid
Color
Transparent colorless to light brown
Usage

Key Intermediate for Pharmaceutical Synthesis: As an aliphatic amine intermediate containing a pyrrolidine structure, it is used in the synthesis of antihistamines, antidepressants, antibacterial drugs (e.g., histamine H1 receptor antagonists, quinolone antibiotics). Its amino group and pyrrolidine ring can construct the active skeleton of drug molecules through alkylation and acylation reactions, optimizing the binding ability between drugs and targets.

Raw Material for Organic Synthesis & Fine Chemicals: Used in the production of fine chemicals such as dyes, fragrances, and surfactants. It also acts as a nucleophile in the synthesis of heterocyclic compounds (e.g., pyrrolidine derivatives, amide compounds) and can serve as a catalyst or ligand in transition metal-catalyzed reactions.

Custom Reagent in Pharmaceutical Chemistry & Materials Field: Applied in structural modification and impurity synthesis during pharmaceutical R&D by pharmaceutical enterprises, as well as the synthesis of functional polymer materials (e.g., polyamides, polyurethanes) in materials science. Additionally, it can be used as a chromatographic reference standard or reaction reagent in analytical chemistry.

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