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Name
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7 - Amino - 3 - chloromethyl - 3 - cephem - 4 - carboxylic acid p - methoxybenzyl ester hydrochloride
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Synonyms
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(6R,7R)-7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester dihydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-3-cephem-4-carboxylic acid p-methoxybenzyl ester; HCl;
7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester hydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride;
(7R)-7-Amino-3-chloromethyl-3-cephem-4-carboxylate p-methoxybenzyl ester hydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2.0)ct-2-ene-2-carboxylate hydrochloride;
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CAS
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113479-65-5
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MF
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C16H18ClN2O4S
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MW
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405.29
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EINECS
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601 - 254 - 0
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Melting Point
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155 - 157°C
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Storage Conditions
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Store in freezer under - 20°C in a dry atmosphere
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Solubility
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Slightly soluble in DMSO, sparingly soluble in ethanol
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Form
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Solid
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Color
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Pale yellow to light brown
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Stability
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Light sensitive
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| Usage |
Key Intermediate for Cephalosporin Antibiotics: As a core precursor for semi-synthetic cephalosporins, it can synthesize broad-spectrum antibiotics such as cefepime and cefixime through nucleophilic substitution of the chloromethyl group and acylation of the amino group, which are used to treat bacterial infections (e.g., respiratory and urinary tract infections). Raw Material for Antibacterial Drug Structural Modification: Its 3-chloromethyl group allows the introduction of different substituents (e.g., heterocycles, amino groups) to optimize the antibacterial spectrum (e.g., enhancing activity against Gram-negative bacteria), stability, and pharmacokinetic properties of drugs, facilitating the research and development of novel cephalosporin drugs. Custom Synthesis Intermediate in Pharmaceutical and Chemical Industry: Used by pharmaceutical enterprises for the customized synthesis of cephalosporin drug intermediates or impurity reference standards, supporting drug quality control, preclinical research, and large-scale production process optimization. |
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