CAS:113479-65-5 7 - Amino - 3 - Chloromethyl - 3 - Cephem - 4 - Carboxylic Acid P - Methoxybenzyl Ester Hydrochloride

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CAS:113479-65-5 7 - Amino - 3 - Chloromethyl - 3 - Cephem - 4 - Carboxylic Acid P - Methoxybenzyl Ester Hydrochloride
Details
Category
Cephalosporin Intermediates
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Description
Name
7 - Amino - 3 - chloromethyl - 3 - cephem - 4 - carboxylic acid p - methoxybenzyl ester hydrochloride
Synonyms
(6R,7R)-7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester dihydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-3-cephem-4-carboxylic acid p-methoxybenzyl ester; HCl;
7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester hydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride;
(7R)-7-Amino-3-chloromethyl-3-cephem-4-carboxylate p-methoxybenzyl ester hydrochloride;
(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2.0)ct-2-ene-2-carboxylate hydrochloride;
CAS 
113479-65-5
MF
C16H18ClN2O4S
MW
405.29
EINECS 
601 - 254 - 0
Melting Point
155 - 157°C
Storage Conditions
Store in freezer under - 20°C in a dry atmosphere
Solubility
Slightly soluble in DMSO, sparingly soluble in ethanol
Form
Solid
Color
Pale yellow to light brown
Stability
Light sensitive
Usage

Key Intermediate for Cephalosporin Antibiotics: As a core precursor for semi-synthetic cephalosporins, it can synthesize broad-spectrum antibiotics such as cefepime and cefixime through nucleophilic substitution of the chloromethyl group and acylation of the amino group, which are used to treat bacterial infections (e.g., respiratory and urinary tract infections).

Raw Material for Antibacterial Drug Structural Modification: Its 3-chloromethyl group allows the introduction of different substituents (e.g., heterocycles, amino groups) to optimize the antibacterial spectrum (e.g., enhancing activity against Gram-negative bacteria), stability, and pharmacokinetic properties of drugs, facilitating the research and development of novel cephalosporin drugs.

Custom Synthesis Intermediate in Pharmaceutical and Chemical Industry: Used by pharmaceutical enterprises for the customized synthesis of cephalosporin drug intermediates or impurity reference standards, supporting drug quality control, preclinical research, and large-scale production process optimization.

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