CAS 209467-59-4 (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one

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CAS 209467-59-4 (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one
Details
CAS No. 209467-59-4
MF C30​H21​N5​O2​S3​
MW 579.72
EINECS No. 447-420-4
Category
Cephalosporin Intermediates
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Description
Name
(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one
Synonyms
(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one; 1,2,4-Thiadiazole-3-ethanethioic acid, 5 - amino - α - [(triphenylmethoxy)imino] - S - 2 - benzothiazolyl ester,
(αZ)-S-(1,3-benzothiazol-2-yl) (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-trityloxyimino-ethanethioate;
(2Z)-(5-Amino-[1,2,4]thiadiazol-3-yl)-trityloxyimino-thioacetic acid S-benzothiazol-2-yl ester;
Daptomycin Impurity 59
CAS No.
209467-59-4
MF
C30​H21​N5​O2​S3​
MW
579.72
EINECS No
447-420-4
Structure
[Show the corresponding structure image]
Boiling Point
768.0±70.0 °C (Predicted)
Density
1.40±0.1 g/cm³ (Predicted)
Acidity Coefficient (pKa):
-1.54±0.10 (Predicted)
Usage

1. Key impurity reference standard for daptomycin synthesis As the β-isomer of daptomycin, it is a characteristic impurity in the production process of daptomycin. It can serve as an impurity reference standard in quality control to detect the content of this isomer in the final product, ensuring the purity and medication safety of daptomycin.

2. Model compound for structure-activity relationship studies of antibiotics Its structure is highly similar to daptomycin but differs in configuration. It can be used to study how the configuration of daptomycin-like antibiotics affects their biological activity, helping to optimize drug molecular structures and enhance antibacterial efficacy.

3. Auxiliary reagent for studying antimicrobial drug resistance mechanisms It can be used as an experimental tool, combined with daptomycin, to explore whether bacterial resistance to this class of lipopeptide antibiotics is related to the isomer structure, providing data support for the development of new anti-drug-resistant bacterial drugs. 

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