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Name
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2 - chloro - 3,4 - bis((4 - methoxybenzyl)oxy)-N-(2-(pyrrolidin - 1 - yl)ethyl)benzamide
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Synonyms
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2 - chloro - 3,4 - bis((4 - methoxybenzyl)oxy)-N-(2-(pyrrolidin - 1 - yl)ethyl)benzamide;
Benzamide, 2 - chloro - 3,4 - bis[(4 - methoxyphenyl)methoxy]-N - [2 - (1 - pyrrolidinyl)ethyl]-;
2 - chloro - 3,4 - di - p - methoxyphenylmethoxy - N - (2 - (1 - pyrrolidinyl)ethyl)benzamide;
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CAS
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1225208 - 44 - 5
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MF
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C29H33ClN2O5
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MW
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525.03572
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Boiling Point
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649.6±55.0 °C (Predicted)
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Density
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1.216±0.06 g/cm³ (Predicted)
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Acid Dissociation Constant (pKa)
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13.40±0.46 (Predicted)
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Usage
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Pharmaceutical R&D Intermediate (Targeted Drug Direction):
As a key intermediate with a benzamide skeleton, it is mainly used in the synthesis of novel targeted drugs (e.g., kinase inhibitors, G protein-coupled receptor modulators). Its pyrrolidin-1-ylethyl side chain can optimize the binding affinity between the drug and the target, while the bis((4-methoxybenzyl)oxy) group enhances the molecular lipophilicity and metabolic stability.
Organic Synthesis Building Block (Functional Group Modification):
Featuring multiple active sites such as chlorine atom, amide bond, and ether bond in the molecule, it can undergo structural derivation through nucleophilic substitution, hydrolysis, coupling, and other reactions. It is used to construct complex heterocyclic compounds or drug candidate libraries, supporting high-throughput screening.
Raw Material for Bioactive Molecular Probe Synthesis:
In biomedical research, it is used to prepare specific molecular probes, facilitating the localization of biological targets (e.g., enzymes, receptors), analysis of binding mechanisms, and research on drug action pathways, thus providing tool support for preclinical drug evaluation.
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