Name: China CAS：289042-12-2 Tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Manufacturers, Suppliers - Factory Direct Wholesale - JECI
Brand: Jeci
SKU: 285505071

Name	tert - Butyl 6 - [(1E)-2 - [4 - (4 - fluorophenyl) - 6 - (1 - methylethyl) - 2 - [methyl(methylsulfonyl)amino] - 5 - pyrimidinyl]ethenyl] - 2,2 - dimethyl - 1,3 - dioxane - 4 - acetate
Synonyms	(4R,6S)-6-[(1E)-2-[4-(4-FLUOROPHENYL)-6-(1-METHYLETHYL)-2-[METHYL(METHYLSULFONYL)AMINO]-5-PYRIMIDINYL]ETHENYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER; tert - Butyl 6 - [(1E)-2 - [4 - (4 - fluorophenyl) - 6 - (1 - methylethyl) - 2 - [methyl(methylsulfonyl)amino] - 5 - pyrimidinyl]ethenyl] - 2,2 - dimethyl - 1,3 - dioxane - 4 - acetate; 6 - [(1E)-2 - [4 - (4 - Fluorophenyl) - 6 - (1 - methylethyl) - 2 - [methyl(methylsulfonyl)amino] - 5 - pyrimidinyl]ethenyl] - 2,2 - dimethyl - 1,3 - dioxane - 4 - acetic acid 1,1 - dimethylethyl ester; Rosuvastatin intermediate R - 2; Tert - Butyl (+) - 7 - [4 - (4 - Fluorophenyl) - 6 - Isopropyl - 2 - (N - Methyl - N - Methyl Sulfonlyamino) Pyrimidine - 5 - yl] - (3R,5S) - Dioxane - (E) - 6 - Heptenoate; Tert - butyl (+) - 7 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - (n - methyl - n - methylsulphonyl amino) pyrimidine - 5 - yl] - (3r,5s) - dioxane - (e) - 6 - heptenate; Tert - butyl (-) - 7 - [4 - (4 - fluorophenyl) - 6 - isopropyl - 2 - (N - methyl - N - methylsulfonylamino)pyrimidine - 5 - yl] - (3R,5S) - dioxane - (E) - 6 - heptenate; Tert - butyl (-) - 7 - [4 - (4 - afluorophenyl) - 6 - isopropyl - 2 - (N - methyl - N - methylsulfonylamino)pyrimidine - 5 - yl] - (3R,5S) - dioxane - (E) - 6 - heptenate
CAS No.	289042 - 12 - 2
MF	C₂₉H₄₀FN₃O₆S
MW	577.71
EINECS No.	1806241 - 263 - 5
Melting Point	153 - 155°C
Boiling Point	673.3±65.0 °C (Predicted)
Density	1.210
Storage Conditions	Inert atmosphere, 2 - 8°C
Solubility	Slightly soluble in chloroform, slightly soluble in methanol
Acid Dissociation Constant (pKa)	-0.43±0.10 (Predicted)
Form	Solid
Color	White to off - white
Usage	1. Core Intermediate for Rosuvastatin Calcium Synthesis: As a key precursor in the production of this lipid-lowering drug, it can construct the core molecular structure of rosuvastatin calcium through subsequent reactions such as hydrolysis and cyclization, serving as an indispensable link in the drug synthesis route. 2. Tool for Pharmaceutical R&D Optimization: In the process improvement of rosuvastatin calcium or the R&D of similar lipid-lowering drugs, it can act as a basic raw material for structural modification. It helps adjust key properties of compounds like lipid solubility and metabolic stability, facilitating the development of new drugs or improved processes. 3. Intermediate for Organic Synthesis Reactions: With functional groups such as ester groups and vinyl groups, it can participate in various organic transformation reactions. Beyond pharmaceutical synthesis, it is also used to synthesize structurally similar carboxylate derivatives, which are applied in the R&D of fine chemical products.

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CAS：289042-12-2 Tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

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