Guaifenesin (CAS: 93-14-1, Synonyms: 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane

1,2-Propanediol, 3-(2-methoxyphenoxy)-; 1,2-Propanediol, 3-(o-methoxyphenoxy)-; 2-G

3-(2-Methoxyphenosy)-1,2-propamediol;glyceryl guaiacolate) is an organic compound with the molecular formula C₁₀H₁₄O₄. It appears as a white crystalline powder with a slight characteristic odor.It is a well-known expectorant primarily used to treat respiratory conditions. It works by thinning and reducing the viscosity of mucus in the bronchi and trachea, making coughs more productive and easing the clearance of phlegm. Widely used as an active pharmaceutical ingredient (API) in over-the-counter (OTC) cough and cold medications to relieve chest congestion caused by the common cold, flu, or bronchitis. Approved by the FDA since 1952, it remains one of the most common generic expectorants globally.

◆Chemical Properties

Melting Point	77-81 °C
Boiling Point	215 °C (19 mmHg)
Density	~1.1825 (est.)
Refractive Index	~1.5550 (est.)
Flash Point	215 °C (19 mm)
Storage Condition	2-8 °C
Solubility	~50 g/L
Acidity Coefficient (pKa)	13.53 ± 0.20 (Predicted)
Form	Solid
Color	White to off-white
Water Solubility	5 g/100 mL (25 °C)

◆Applications

Sr. No.	Description	Application
1	Active Pharmaceutical Ingredient (API)	Used as an expectorant in OTC and prescription cough, cold, and bronchitis medications to loosen and clear mucus from the airways.
2	Pharmaceutical Formulation Component	Incorporated into various solid and liquid dosage forms such as tablets, syrups, and extended-release capsules.
3	Drug Intermediate	Serves as a key starting material or intermediate in the synthesis of more complex pharmaceutical compounds.