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Name
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Riboflavin
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|---|---|
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Synonyms
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vitasano2; xypentyl);
Riboflavin (1.07609);
Riboflavin Vitamin B2;
Vitamin B2 (Riboflavine);
RIBOFLAVIN DC GRADE;
RIBOFLAVIN USP (VITAMIN B-2)
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CAS Number
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83-88-5
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Molecular Formula
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C17H20N4O6
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Molecular Weight
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376.36
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EINECS Number
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201-507-1
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Melting Point
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290 °C (dec.) (lit.)
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Specific Optical Rotation
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-135 ° (c=5, 0.05 M NaOH)
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Boiling Point
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504.93 °C (rough estimate)
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Density
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1.2112 (rough estimate)
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Bulk Density
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100 kg/m³
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Refractive Index
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-135 ° (C=0.5, JP Method)
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Flash Point
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9 °C
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Storage Conditions
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2 - 8 °C
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Solubility
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Slightly soluble in water, almost insoluble in ethanol (96%). It undergoes discoloration upon exposure to light, especially in the presence of alkali. It shows polymorphism (5.9).
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Form
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Powder
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Acid Dissociation Constant (pKa)
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1.7 (at 25 °C)
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Color
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Yellow to orange - viscous to waxy
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pH Value
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5.5 - 7.2 (0.07 g/L, H₂O, 20 °C)
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Odor
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Slight odor
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pH Range for Acid - Base Indicator Color Change
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6
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Biological Source
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Synthetic
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Optical Rotation
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[α]/D -135.0 to -155.0°, c = 0.5% in 0.05 M NaOH (dry basis)
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Water Solubility
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0.07 g/L (20 °C)
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Usage
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Riboflavin is found in green vegetables, soybeans, rice, wheat, yeast, liver, heart and dairy products. In the human body, riboflavin is distributed in various tissues, where it constitutes a coenzyme in the body's hydrogen transfer system. It participates in redox reactions and plays a role in transferring hydrogen atoms. When riboflavin is deficient, biological oxidation is affected, leading to metabolic disorders. The resulting lesions mostly occur in the mouth, eyes and external genitalia, such as angular cheilitis, cheilitis, conjunctivitis and scrotitis.
Riboflavin is mainly used as a pharmaceutical, food additive and feed additive. In pharmaceutical applications, it is used in compound vitamins or vitamin B2 preparations, and also serves as a yellow colorant for sugar-coated tablets and capsules. When used as a food additive, it not only has the function of nutritional fortification, but also acts as a yellow colorant. The LD50 (median lethal dose) of riboflavin in rats via intraperitoneal injection is 560 mg/kg.
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