At present, the quinolone antibacterial drugs developed in the market and put into mass production mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin intermediates, lomefloxacin, fleroxacin, etc. Among them, norfloxacin, ciprofloxacin, and ofloxacin have the largest production volume, accounting for about 98% of the total domestic production of fluoroquinolone antibacterial drugs.
Quinolones are generally synthesized from fluorine-containing benzene ring to synthesize fluorine-containing quinoline compounds and then condensed with piperazine (or methylpiperazine). With abundant reserves of fluorite, China is one of the countries with the largest production of fluorine-containing drugs and intermediates in the world. More than 80% of fluorine-containing intermediates are supplied for export. On the whole, China's fluorobenzene intermediates developed earlier, and the current production capacity is generally surplus. The development of trifluorotoluene intermediates is relatively late and has developed rapidly in recent years. For heterocyclic aromatic compounds, especially fluorine-containing pyridines, currently only a few research units and manufacturers in China have the synthesis technology of fluorine-containing pyridine intermediates . Therefore, fluorine-containing pyridine intermediates will become one of the main directions for the research and development of fluorine-containing intermediates in China in the next few years. China has become the world's largest producer of antipyretic and analgesics. The output of aspirin, paracetamol, and Analgin all exceeded 10,000 tons, and the output of phenacetin, aminopyrine, and antipyrine exceeded 1,000 tons. At present, the output of antipyretic and analgesics in China is growing rapidly, and it is expected to increase at a rate of about 8% in the future. The production of intermediates supporting the production of antipyretic and analgesics is large and there are many manufacturers. With the growth of antipyretic and analgesic drugs, its enoxacin intermediates have also made considerable progress.
