Professor Lu Hongzhou of the Haishi Municipal Public Health Clinical Center and the team of Professor Chen Min from Shanghai First People’s Hospital Affiliated to Shanghai Jiaotong University selected 97 patients with new coronary pneumonia admitted to the Shanghai Public Health Clinical Center from January 20 to February 20 ( Among them, 85 were non-critical patients, 12 were critically ill patients), and 227 patients who were diagnosed and treated at Shanghai First People’s Hospital during the same period (12 of which were confirmed patients with new coronary disease, 24 were patients with suspected new coronary disease, and 15 were patients Influenza pneumonia patients, 176 patients were other pneumonia patients). A total of 324 patients were compared and analyzed. The results found that the peripheral blood eosinophil (EOS) counts in patients with new coronary pneumonia that few people paid attention to in the past were high and low. The early diagnosis of the disease is of great significance. The results were recently published in "Allergy".
Lu Hongzhou introduced that EOS is a type of inflammatory cell, and its number generally increases in diseases such as allergic diseases and parasitic infections, but the significance of its "decrease" in diseases has rarely been paid attention to. In the process of diagnosing and treating patients with new coronary pneumonia, the researchers found that most patients have reduced EOS, and some patients cannot even be detected. This is different from previous coronavirus infections (such as SARS and MERS), and as the condition improves, EOS The number will gradually recover. In order to confirm this result, the research team further collected relevant data for analysis, and found that EOS behaves differently in patients with different severity of new coronary pneumonia. The degree of decrease in mild patients is small, while the number of EOS in severe patients has decreased significantly. In the 12 severely ill patients included in the hospital, no EOS was detected at all; and the number of mildly ill patients recovered quickly after the decrease in EOS, while the severely ill patients recovered very slowly, or even never recovered. Later, the research team compared the change trend of EOS with several indicators (such as body temperature, improved imaging, and negative nucleic acid) that reflect the improvement of the condition and discharge standards, and this result was also confirmed. Further observation found that if the patient's condition improves, first the body temperature is normal, then EOS returns to normal, followed by improvement in imaging, and finally the nucleic acid turns negative.
Among the patients with new coronary pneumonia admitted to the Shanghai Public Health Clinical Center, the EOS count of the vast majority of patients (71.7%) decreased or disappeared; among the patients diagnosed and treated for fever in Shanghai First People's Hospital, among the patients with confirmed new coronary pneumonia 41.7% of patients had a lower EOS count, and the incidence was significantly higher than that of patients with suspected new coronary pneumonia, influenza pneumonia and other pneumonia. Therefore, the EOS count has important auxiliary significance for the diagnosis of new coronary pneumonia.
Lu Hongzhou further elaborated that the EOS count is closely related to the early diagnosis and severeization of patients with new coronary pneumonia. Patients with a low EOS count at admission are more likely to have clinical symptoms such as fever and shortness of breath, and chest CT and X-rays show that their condition is aggravated, and their hospitalization time and course of disease are longer. The recovery of EOS count indicates a good prognosis for patients with new crown. From the beginning of the onset, after the EOS count of patients with new coronary pneumonia has dropped significantly, with treatment, the EOS level will gradually rise and return to the normal level on the 16th day; the EOS level of non-severe patients with new coronary pneumonia recovers faster than severe patients, generally It will return to normal in 12 days. Therefore, by detecting changes in the number of EOS, combined with other disease indicators, the disease outcome of new coronary patients can be more comprehensively grasped, and at the same time it has predictive value for the improvement of other indicators of patients.
