Description

2-Fluoro-4-nitrobenzoic acid (CAS: 403-24-7, Synonyms: (2-Fluoro-4-nitrobenzotcacid;0083512-Fluoro-4-nitrobenzoicacid;2-Fluoro-4-nitrobenzoicacid98+%;4-Carboxy-3-fluorChemicalbookonitrobenzene;2-Fluor-4-nitrobenzoicacid;NSC190361;2-Fluoro-4-nitrobenzoicacid97%;Benzoicacid,2-fluoro-4-nitro-) is a fluorinated and nitrated aromatic carboxylic acid that serves as a versatile synthetic intermediate in pharmaceutical and agrochemical industries, primarily used in the synthesis of fluorinated drug candidates (e.g., antimicrobial and anti-inflammatory agents) and advanced functional materials. Its structure combines reactive fluorine and nitro groups, enabling efficient functionalization in organic synthesis.

◆Chemical Properties

Property	Value
Melting Point	170 °C
Boiling Point	352.5±27. 0 °C (Predicted)
Density	1.568±0.06 g/cm³ (Predicted)
Storage Conditions	Sealed in dry, Room Temperature
Appearance	Powder crystal
Acid Dissociation Constant (pKa)	2.37±0.13 (Predicted)
Color	White to pale yellow to pale orange
BRN	2582091

◆Applications

Sr. No.	Description	Application
1	Key intermediate for nucleoside & nucleotide synthesis	Antiviral & anticancer drug development (e.g., nucleoside reverse transcriptase inhibitors, purine analogs)
2	Building block for modified nucleosides	Design and synthesis of prodrugs & targeted therapeutics
3	Precursor for bioactive purine derivatives	Synthesis of enzyme inhibitors & immunomodulatory agents
4	Scaffold for medicinal chemistry optimization	Lead compound generation & structure - activity relationship (SAR) studies
5	Reagent for derivatization in drug analysis	HPLC/GC sample preparation & impurity profiling in pharmaceutical R&D

◆Product Specifications

2-Fluoro-4-nitrobenzoic acid (CAS NO.403-24-7) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

Use appropriate personal protective equipment (PPE)
Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
Handle in controlled, well-ventilated environments
Keep away from heat, sparks, open flames and hot surfaces
Protect from moisture and avoid contact with water
Follow chemical handling, storage and containment protocols
Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

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