Description

Bromotrimethylsilane (CAS: 2857-97-8, Synonyms: (TMBS,Trimethylbromosilane,Trimethylsilylbromide;BromotrimethylsilaneTrimethylsilylbromide;Bromotrimethylsilane,TMBS,Trimethylbromosilane,Trimethylsilylbromide;BromoChemicalbooktrimethylsilane,AcroSeal,98%;BroMotriMethylsilane,Stab.WithCopperPowderorSilverWire;Bromotrimethylsilane,98%;Trimethylsilylbromide,TMBS;BroMotriMethylsilane,98%100GR) a colorless, volatile, and flammable liquid that is soluble in benzene, diethyl ether, and perchloroethylene. It hydrolyzes upon contact with water, releasing free hydrochloric acid. It serves as an excellent reagent for introducing the trimethylsilyl group into organic molecules. Combining the properties of both inorganic and organic materials, it exhibits excellent characteristics such as resistance to high and low temperatures, electrical insulation, ozone resistance, radiation resistance, flame retardancy, water repellency, corrosion resistance, non-toxicity, odorlessness, and biological inertness. It is widely used in industries such as electronics, electrical equipment, construction, chemicals, textiles, light industry, medical, and chemical production. It can be used as an intermediate in the production of organic silicon polymers and organic synthesis reactions. Additionally, it serves as a capping agent for high-molecular-weight compounds, a desiccant, a dehydrating agent, a raw material for high-temperature adhesives and resins, and is commonly used in pharmaceutical production for the synthesis of cephalosporin I and cephalosporin V.

◆Chemical Properties

Melting Point	-43 °C
Boiling Point	79 °C (lit.)
Density	1.16 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.424 (lit.)
Flash Point	90 °F
Storage Conditions	Store below +30°C.
Solubility	Decomposes in water
Form	Liquid
Color	Transparent colorless to yellow
Specific Gravity	1.1725

◆Applications

Sr. No.	Description	Application
1	Key reagent for protecting hydroxyl groups in nucleosides/nucleotides	Synthesis of antiviral/anticancer nucleoside prodrugs (e.g., kinase inhibitors)
2	Building block for silyl - protected intermediates	Design of prodrugs to improve drug solubility/stability (e.g., peptide - nucleic acid conjugates)
3	Precursor for bioactive silyl - containing derivatives	Development of enzyme inhibitors (e.g., sirtuin modulators) & immunomodulatory agents
4	Scaffold for medicinal chemistry optimization	Lead compound generation & structure - activity relationship (SAR) studies (e.g., small - molecule modulators)
5	Derivatization reagent for drug analysis	HPLC sample preparation & impurity profiling in pharmaceutical R&D (e.g., active pharmaceutical ingredient (API) analysis)

◆Product Specifications

Bromotrimethylsilane (CAS NO.2857-97-8) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

Use appropriate personal protective equipment (PPE)
Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
Handle in controlled, well-ventilated environments
Keep away from heat, sparks, open flames and hot surfaces
Protect from moisture and avoid contact with water
Follow chemical handling, storage and containment protocols
Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

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