Description

N,N'-Diisopropylcarbodiimide (CAS: 693-13-0, Synonyms: (Carbodiimide,diisopropyl-;diisopropyl-carbodiimid;N,N'-Diisopropylcarbodiimide≥99%(Assay);N,N'-Diisopropylcarbodiimideforsynthesis;n,n'-methanetetraylbis(2-propanamine);1,3-DChemicalbookIISOPROPLYCARBODIIMIDE;N,N'-DIISOROPYLCARBODIMIDEextrapure;DICimpregnatedtablets,ChemDose(R),N,Nμ-Diisopropylcarbodiimidetablets,N,Nμ-Diisopropylcarbodiimideimpregnatedtablets) is primarily used as a dehydrating agent for amikacin and glutathione, and can also be employed in the synthesis of acid anhydrides, aldehydes, ketones, and isocyanates. As a dehydration-condensation reagent, it can react at room temperature within a short period, with the reaction product being diisopropylurea. Additionally, DIC can be utilized in the synthesis of peptides and nucleic acids. Using this reagent, peptides can be easily synthesized from compounds containing free carboxyl groups and free amino groups at room temperature. It is widely applied in pharmaceuticals, health products, cosmetics, biological agents, and other organic synthesis fields.

◆Chemical Properties

Melting Point

210–212 °C (dec)

Boiling Point

145–148 °C (lit.)

Density

0.815 g/mL at 20 °C (lit.)

Vapor Pressure

34.9 hPa at 55.46 °C

Refractive Index

n₂₀/D 1.433 (lit.)

Flash Point

93 °F

Storage Conditions

Store below +30 °C.

Solubility

Soluble in chloroform, dichloromethane, acetonitrile, dioxane, dimethylformamide and tetrahydrofuran.

Form

Liquid

Color

Transparent colorless to yellow

Sensitivity

Moisture Sensitive

BRN

878281

◆Applications

Sr. No.	Description	Application
1	Key coupling reagent for amide bond formation	Synthesis of peptide - based drugs (e.g., therapeutic peptides for diabetes/hypertension) and peptide - drug conjugates
2	Reagent for activating carboxylic acids	Preparation of prodrugs (e.g., ester - linked prodrugs to enhance oral bioavailability) and peptide - nucleic acid conjugates
3	Intermediate for heterocyclic compound synthesis	Development of kinase inhibitors (e.g., tyrosine kinase modulators) and enzyme - targeted therapeutics
4	Building block for pharmaceutical intermediates	Lead compound generation & structure - activity relationship (SAR) studies in central nervous system (CNS) drugs (e.g., antidepressants)
5	Reagent for protein cross - linking in biopharmaceutical R&D	Formulation optimization of antibody - drug conjugates (ADCs) and stabilization of therapeutic proteins
6	Reagent for derivatization in drug impurity profiling	HPLC/GC sample preparation for quality control of antihypertensive and antidiabetic drugs

◆Product Specifications

N,N'-Diisopropylcarbodiimide (CAS NO.693-13-0) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

Use appropriate personal protective equipment (PPE)
Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
Handle in controlled, well-ventilated environments
Keep away from heat, sparks, open flames and hot surfaces
Protect from moisture and avoid contact with water
Follow chemical handling, storage and containment protocols
Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

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