Description
D-(+)-Glucono-1,5-lactone (CAS: 90-80-2, Synonyms: (Calbiochem;GluconoDeltaLactone,GluconoDeltaLactonepowder;CagliflozinImpurity8;delta-GluconolactoneinstockGMPFactory;1,2Chemicalbook,3,4,5-PENTAHYDROXYCAPROICACIDDELTA-LACTONE;DELTA-GLUCURONOLACTONE;D(+)-DEXTRONICACIDDELTA-LACTONE;D-GLUCONICACIDLACTONE) is an ester formed by the dehydration between the carboxyl group of gluconic acid and the hydroxyl group within the molecule. Specifically, the ester formed by dehydration with the hydroxyl group on the 5th (δ-position) carbon atom is called glucono-δ-lactone; the ester formed by dehydration with the hydroxyl group on the 4th (γ-position) carbon atom is called glucono-γ-lactone. It appears as crystals with a sweetness different from gluconic acid. It decomposes at 153°C, with a specific rotation [α]D20 of +61.7° (C=1). It is highly soluble in water, where it hydrolyzes to form gluconic acid, establishing an equilibrium mixture with both δ- and γ-lactones. Structurally, gluconolactone and its phosphate esters are intermediates in the oxidative breakdown of glucose (the pentose phosphate pathway) in living organisms. In food processing, it serves as a coagulant for soybean or milk proteins, a preservative for meat, a leavening agent for pastries, and a stabilizer for pigments.
◆Chemical Properties
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Melting Point |
160 °C (dec.) (lit.) |
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Specific Rotation |
65 ° (c=1, H2O) |
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Boiling Point |
230.35 °C (rough estimate) |
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Bulk Density |
750 kg/m³ |
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Density |
0.6 |
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Refractive Index |
63.5 ° (C=10, H2O) |
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Storage Conditions |
Sealed in dry, Room Temperature |
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Solubility |
Solubility in water is 590 g/L |
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Acid Dissociation Constant (pKa) |
12.06 ± 0.60 (Predicted) |
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Form |
Crystalline powder |
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Color |
White to off-white |
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Odor |
White crystals, powder, odorless |
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pH Value |
3.6 (10 g/L, H2O, 20 °C) |
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◆Applications
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◆Product Specifications
D-(+)-Glucono-1,5-lactone (CAS NO.90-80-2) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.
- Use appropriate personal protective equipment (PPE)
- Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
- Handle in controlled, well-ventilated environments
- Keep away from heat, sparks, open flames and hot surfaces
- Protect from moisture and avoid contact with water
- Follow chemical handling, storage and containment protocols
- Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information
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