Description

N-Acetyl-D-leucine (CAS: 19764-30-8, Synonyms: (2-Acetylamino-4-methylvalericacid;N-Acetyl-2-isobutylglycine;D-2-Acetylamino-4-methylvalericacid;2,N-Acetyl-D-leuChemicalbookcine;(R)-2-acetaMido-4-Methylpentanoicacid;D-Leucine,N-acetyl-;N-Ac-D-Leu-OH;(R)-Ac-2-amino-4-methylpentanoicacid) is a chiral acetylated amino acid derivative primarily used as a key pharmaceutical intermediate and chiral building block in the synthesis of peptide-based therapeutics, neuromodulators, and prodrugs, with applications in neurological disorder research and metabolic disease studies. It is typically supplied as a white crystalline powder with high optical purity, complying with pharmacopeial standards, and requires storage at 2–8°C.

◆Chemical Properties

Melting Point

176–177 °C

Boiling Point

369.7 ± 25.0 °C (Predicted)

Density

1.069 ± 0.06 g/cm³ (Predicted)

Refractive Index

23 ° (C=4, EtOH)

Storage Conditions

Sealed in dry condition; store in freezer under −20 °C

Solubility

Slightly soluble in DMSO; slightly soluble in ethanol (with ultrasonic treatment); slightly soluble in methanol

Appearance/Form

Solid

Acid Dissociation Constant (pKa)

3.67 ± 0.10 (Predicted)

Color

White to off-white

◆Applications

Sr. No.	Description (of N - Acetyl - D - leucine)	Application in Pharmaceutical Industry
1	Natural antioxidant & precursor for glucuronic acid conjugates	Synthesis of hepatoprotective drugs (e.g., for liver detoxification support) and antidotes for heavy metal poisoning
2	Chelating agent for metal ions	Development of chelation therapy drugs (e.g., for iron/copper overload disorders like hemochromatosis)
3	Key intermediate for glucuronide - based prodrugs	Design of prodrugs to enhance water solubility and renal excretion (e.g., for anticancer or antiviral agents)
4	Scaffold for medicinal chemistry optimization	Lead compound generation & structure - activity relationship (SAR) studies in metabolic disease therapeutics

◆Product Specifications

N-Acetyl-D-leucine (CAS NO.19764-30-8) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

Use appropriate personal protective equipment (PPE)
Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
Handle in controlled, well-ventilated environments
Keep away from heat, sparks, open flames and hot surfaces
Protect from moisture and avoid contact with water
Follow chemical handling, storage and containment protocols
Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

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