Penciclovir Basic information
|
Product Name: |
Penciclovir |
|
Synonyms: |
9-[4-hychoxy-3-(hydvoxymethyl)butyl]guanine;BRL-39123;BRL-39123A;PCV;Vectavir;PENCICLOVIR-D4;Penciceovir;6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]- |
|
CAS: |
39809-25-1 |
|
MF: |
C10H15N5O3 |
|
MW: |
253.26 |
|
EINECS: |
663-371-3 |
Penciclovir Chemical Properties
|
Melting point |
275-277°C |
|
Boiling point |
653.4ºC±65.0 °C(Predicted) |
| density | 1.68±0.1 g/cm3(Predicted) |
|
Storage Condition |
Keep in dark place,Sealed in dry,Store in freezer,under -20℃ |
| solubility | 0.02 M potassium phosphate: soluble2mg/mL |
| pka | 14.42±0.10(Predicted) |
| color | White to Off-White |
| Form | White soild |
| λmax | 253nm(H2O)(lit.) |
|
Merck |
14,7083 |
Penciclovir Usage And Synthesis
| Description | Vectavir was launched in the UK for herpes labialis. Penciclovir is synthetically available by two routes of four steps each from 2- (hydroxymethyl)butane-l,4-diol and is active against HSV-1, HSV-2 VZV but has limited activity against CMV. Vectavir is an acyclic guanosine analog that acts as a competitive inhibitor of DNA polymerase. It is a metabolic product of famcyclovir that is preferentially phosphorylated by viral infected cells (by thymidine kinases) over normal cells. The triphosphate has a low activity against cellular DNA polymerase which is one possible explanation for its low toxicity. While its spectrum of activity is similar to acyclovir, it is longer acting because its triphosphate is 20 times more stable and is not metabolized. |
| Chemical Properties | White Cyrstalline Solid |
| Uses | A deuterated version of Penciclovir,an antiviral. |
|
Indications |
Penciclovir has activity against HSV-1, HSV-2, VZV, and HBV. After oral administration, famciclovir is converted to penciclovir by first-pass metabolism. Penciclovir has a mechanism of action similar to that of acyclovir. It is first monophosphorylated by viral thymidine kinase; then it is converted to a triphosphate by cellular kinases. |
It is nucleoside antiviral drugs, it can inhibit herpes simplex virus type I and type II in vitro. In virus infected cells, viral thymidine kinase phosphorylates the product to penciclovir monophosphate, and then cell kinase converts penciclovir monophosphate into penciclovir triphosphate. In vitro experiments showed that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibited herpes simplex virus polymerase, thus selectively inhibited the synthesis and inhibition of herpes simplex virus DNA.
Hot Tags: penciclovir cas no 39809-25-1, China, manufacturers, suppliers, factory, custom, wholesale
