Ketorolac tromethamine Basic information
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Product Name: |
Ketorolac tromethamine |
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Synonyms: |
KETOROLAC TRIS SALT;KETOROLAC TROMETHAMINE;KETOROLAC TROMETHAMINE SALT;(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID, TRIS (HYDROXYMETHYL) AMINOMETHANE SALT;(+/-)-5-benzoyl-2,3-dihydro-1h-pyrrolizine-1-carboxylic acid tris(hydroxymethyl)methylamine salt;(+/-)-5-BENZOYL-2,3-DIHYDRO-1H-PYRROLIZINE-1-CARBOXYLIC ACID TRIS SALT;KETROLAC TROMETHAMINE SALT;(±)-Form tromethamine salt |
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CAS: |
74103-07-4 |
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MF: |
C19H24N2O6 |
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MW: |
376.41 |
Ketorolac tromethamine Chemical Properties
| Melting point | 160-161 C |
| storage temp. | 2-8°C |
| solubility | H2O: 15 mg/mL stable at least one month at −20 °C., soluble |
| form | crystalline |
| color | White to Light yellow |
| λmax | 322nm(MeOH)(lit.) |
| Merck | 14,5306 |
| Stability: |
Hygroscopic |
Ketorolac tromethamine Usage And Synthesis
| Description | Ketorolac tromethamine is a nonsteroidal antiinflammatory agent that exhibits analgesic and antipyretic activity. The compound is effective in the management of moderate to severe postoperative pain. It is, however, the first of this type of agent to be administered parenterally as an analgesic and is specifically indicated for intramuscular injection. Ketorolac represents a useful alternative to the narcotic analgesics due to its lack of abuse potential. |
| Chemical Properties | Off-White to Pale Yellow Solid |
| Uses | Ketorolac tromethamine is a non - steroidal anti - inflammatory drug mainly used for analgesia, capable of relieving moderate to severe pain. Its mechanism of action is to inhibit the activity of cyclooxygenase and reduce the synthesis of prostaglandins. Clinically, it is often used for postoperative pain relief, etc., but may also cause adverse reactions such as gastrointestinal discomfort. |
It belongs to NSAIDs, which can inhibit the biosynthesis of prostaglandins, and its biological activity is related to its S-type structure. Animal studies have shown that this medicine has analgesic effects, but has no sedative and anti-anxiety effects. The drug can reduce the level of prostaglandin E2 in aqueous humor after ocular administration, and prevent inflammatory mediators from irritating and damaging the eyes.
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