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Name
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daprodustat
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|---|---|
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Synonyms
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daprodustat;Daprodustat;
2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid;
N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine;
DAPRODUSTAT; 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid;
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|
CAS No.
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960539-70-2
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|
MF
|
C19H27N3O6
|
|
MW
|
393.43
|
|
EINECS No.
|
691-659-9
|
|
Melting Point
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237 - 241 °C
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|
Density
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1.359 ± 0.06 g/cm³ (Predicted)
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|
Storage Conditions
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Refrigerator
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|
Solubility
|
Slightly soluble in chloroform, slightly soluble in DMSO
|
|
Acid-Base Coefficient (pKa)
|
3.44 ± 0.10 (Predicted)
|
|
Morphology
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Solid
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|
Color
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White to off - white
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|
Usage
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Used for treating anemia associated with chronic kidney disease (CKD), especially suitable for patients who cannot accept or are intolerant to traditional injectable erythropoiesis-stimulating agents (such as EPO). As an oral HIF-PHI drug, it reduces HIF-α degradation by inhibiting HIF-PH, thereby increasing the production of endogenous erythropoietin (EPO) to alleviate anemia.
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