Sitagliptin phosphate Basic information
| Product Name: | Sitagliptin phosphate |
| Synonyms: | (3R)-3-aMino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;Sitagliptin phosphate/Sitagliptin phosphate Monohydrate/Sitagliptin;Sitagliptin phosphate 4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazin-7(8H)-yl)-4-(2,4,5-t;sitagpliptin;4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate;Sitagliptin phosphate;7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine-phosphate |
| CAS: | 654671-78-0 |
| MF: | C16H18F6N5O5P |
| MW: | 505.31 |
| EINECS: | 1806241-263-5 |
Sitagliptin phosphate Chemical Properties
| Melting point | 202-204°C |
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly, Heated), Water (Sparingly, Sonicated) |
| form | Solid |
| color | White to Off-White |
Sitagliptin phosphate Usage And Synthesis
| Description | Sitagliptin is the first novel dipeptidyl peptidase IV inhibitor from Merck for the treatment of type 2 diabetes without weight gain and the incidence of hypoglycemia was similar to placebo. Sitagliptin acts by enhancing the body's incretin system, which helps to regulate glucose by affecting β and α cells in the pancreas. |
| Chemical Properties | White Solid |
| Uses | A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes. |
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![3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride CAS NO.762240-92-6](/uploads/202324095/small/3-trifluoromethyl-5-6-7-8-tetrahydro-1-2-43e12f678-9d86-470c-bb91-83425a67cc29.jpg)
