What are cephalosporin intermediates for antibacterial drugs?
Cephalosporin intermediates are core key raw materials for synthesizing cephalosporin antibacterial drugs and serve as important intermediate products linking basic chemical feedstocks to cephalosporin active pharmaceutical ingredients (APIs).
Most of these intermediates are semi-synthetic compounds containing a β-lactam ring. The main representatives include 7-Aminocephalosporanic acid (7-ACA) and 7-Aminodesacetoxycephalosporanic acid (7-ADCA), which must be prepared through precise chemical synthesis or biotechnological fermentation processes. Their structural modifications directly determine the antimicrobial spectrum, activity, and stability of the final product, and they represent the core step in optimizing the efficacy of cephalosporins against Gram-positive and Gram-negative bacteria and in reducing drug resistance.
As an important subfield of the pharmaceutical chemical industry, the purity, yield, and quality stability of cephalosporin intermediates strictly comply with international pharmacopoeial standards such as USP and EP. They are widely used in the production of clinically common antibacterial drugs such as cefazolin, cefuroxime, and ceftriaxone, making them a critical link in the industrial chain that ensures the supply of antibacterial therapeutic agents.
-
![CAS:229016-73-3 PyridiniumM, 4 - [2 - [(6R,7R) - 2 - Carboxy - 7 - [(2Z) - (ethoxyimino)[5 - (phosphonoamino) - 1,2,4 - Thiadiazol - 3 - Yl]acetyl]amino] - 8 - Oxo - 5 - Thia - 1 - Azabicyclo[4.2.0]oct - 2 - En - 3 - Yl]thio] - 1 - Methyl - Pyridinium Inner Salt]()
-
![CAS：866021 - 48 - 9 Ceftaroline;]()
-
![CAS：400827-64-7 7β - Amino - 3 - [4 - (pyridin - 2 - Thiazole Sulfone Radical)] - 3 - Cephem - 4 - Carboxylic Acid·2HCl]()
CAS：400827-64-7 7β - Amino - 3 - [4 - (pyridin - 2 - Thia...CAS 400827 - 64 - 7MF C₁₆H₁₅ClN₄O₅S₃MW 479.42424 -
![CAS 7154-73-6 1-(2-Aminoethyl)pyrrolidine]()
-
![CAS 137088-65-4 (Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)aceticacid]()
CAS 137088-65-4 (Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopr...CAS 137088-65-4MF C18H27N3O7SMW 429.49 -
![CAS：1225208-44-5 2-chloro-3,4-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide]()
CAS：1225208-44-5 2-chloro-3,4-bis((4-methoxybenzyl)oxy)-N...CAS 1225208-44-5MF C29H33ClN2O5MW 525.0357 -
![CAS：113479-65-5 7 - Amino - 3 - Chloromethyl - 3 - Cephem - 4 - Carboxylic Acid P - Methoxybenzyl Ester Hydrochloride]()
-
![CAS 209467-59-4 (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one]()
CAS 209467-59-4 (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-...CAS No. 209467-59-4MF C30H21N5O2S3MW 579.72EINECS No. 447-420-4 -
![CAS 173604-87-0 (5 - Methyl - 2 - Oxo - 1,3 - Dioxol - 4 - Yl)methyl 4 - Nitrophenyl Carbonate]()
CAS 173604-87-0 (5 - Methyl - 2 - Oxo - 1,3 - Dioxol - 4 ...CAS 173604-87-0MF C12H9NO8MW 295.2 -
![CAS:376653-42-8 Phosphonium, [(3'R)-1'-[(1,1-dimethylethoxy)carbonyl]-2-oxo[1,3'-bipyrrolidin]-3-yl]triphenyl-, Bromide]()
CAS:376653-42-8 Phosphonium, [(3'R)-1'-[(1,1-dimethyletho...CAS 376653-42-8MF C31H36BrN2O3PMW 595.51 -
![CAS：376653-43-9 Ceftobiprole Medocaril]()
-
![N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic Acid Tert-butyl Ester CAS NO.:689293-69-4]()
N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4...CAS: 689293-69-4MF: C31H36N6O3MW: 540.66EINECS： 614-818-6
![CAS:229016-73-3 PyridiniumM, 4 - [2 - [(6R,7R) - 2 - Carboxy - 7 - [(2Z) - (ethoxyimino)[5 - (phosphonoamino) - 1,2,4 - Thiadiazol - 3 - Yl]acetyl]amino] - 8 - Oxo - 5 - Thia - 1 - Azabicyclo[4.2.0]oct - 2 - En - 3 - Yl]thio] - 1 - Methyl - Pyridinium Inner Salt](/uploads/24095/small/cas-229016-73-3-pyridiniumm-4-2-6r-7r-25d47f.png?size=380x0)
![CAS：400827-64-7 7β - Amino - 3 - [4 - (pyridin - 2 - Thiazole Sulfone Radical)] - 3 - Cephem - 4 - Carboxylic Acid·2HCl](/uploads/24095/small/cas-400827-64-7051db.png?size=380x0)
![CAS 209467-59-4 (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-[(triphenylmethoxy)imino]ethan-1-one](/uploads/24095/small/cas-209467-59-41e874.png?size=380x0)
![CAS:376653-42-8 Phosphonium, [(3'R)-1'-[(1,1-dimethylethoxy)carbonyl]-2-oxo[1,3'-bipyrrolidin]-3-yl]triphenyl-, Bromide](/uploads/24095/small/cas-376653-42-85857c.png?size=380x0)
![N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic Acid Tert-butyl Ester CAS NO.:689293-69-4](/uploads/24095/small/cas-no-689293-69-4ecf11.png?size=380x0)
Classification of Cephalosporin Intermediates
1. 7-ACA Nucleus-Derived Intermediates
Synthesized via side-chain modification using 7-Aminocephalosporanic Acid (7-ACA) as the core nucleus:Including: Cefdinir Intermediates (aminothiazole side-chain modified), Ceftobiprole Pivoxil Intermediates (pyrrolidone side-chain modified), Ceftolozane Intermediates (oxazolidinone side-chain modified), Ceftaroline Fosamil Intermediates (thiomorpholine side-chain modified).
2. 7-ADCA Nucleus-Derived IntermediatesUsing
7-Amino-3-deacetoxycephalosporanic Acid (7-ADCA) as the core nucleus, corresponding to intermediates for first-generation cephalosporins (e.g., Cefalexin, Cefradine).
3. GCLE Nucleus-Derived Intermediates
Using GCLE (7-Phenylacetamido-3-chloromethyl-4-cephalosporanic Acid p-Methoxybenzyl Ester) as the core nucleus, these are precursor intermediates for semi-synthetic cephalosporins and can be further modified into intermediates for various cephalosporin drugs.
We're well-known as one of the leading cephalosporin intermediates manufacturers and suppliers in China. Our factory offers high quality cephalosporin intermediates made in China with competitive price. Welcome to contact us for wholesale service.
